Biomarkers of Inflammation and Renal Insufficiency in Aged Cognitively Impaired Lead Investigator: Jeanna Winchester Institution : University of California at Irvine E-Mail : jeannawinchester@gmail.com Proposal ID : 152 Proposal Description: Recent research has shown that between 20 and 70 of chronic kidney disease patients suffer from symptoms of cognitive impairment that may go undiagnosed in the community ranging from mild to severe symptomatology. There are several vascular and non-vascular based risk factors for developing cognitive impairment in chronic kidney disease. This evidence suggests the need for continued evaluation of the relationship between markers of chronic kidney disease and cognitive decline. Though, currently, there exists only a limited amount of research in this area, the current NACC data analaysis seeks to build on this body of evidence. The current study proposes to examine, via neuropsychological and serum testing, the relationship between biomarkers indicative of chronic kidney disease and cognitive impairments in data retrieved from the NACC dataset. The purpose this examination will be to determine if individuals with poorer biomarker levels of renal function, daily and exercise activity perform worse on measures of cognitive function than individuals with higher biomarker levels of renal function, daily and exercise activity. Then, this examination will seek to determine if this relationship is affected by the presence of diabetes, age, gender, education or genotype.